| WU Ying,ZHAO Wenzhen,LIU Qiang.Use of rhGM-CSF and rhEPO in rescuing 3 patients with acute radiation sickness[J].Chinese Journal of Radiological Medicine and Protection,2001,21(3):178-180 |
| Use of rhGM-CSF and rhEPO in rescuing 3 patients with acute radiation sickness |
| Received:February 12, 2001 |
| DOI： |
| KeyWords:Acute radiation sickness rhGM-CSF rhEPO Serum concentration |
| FundProject: |
| Author Name | Affiliation | | WU Ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | ZHAO Wenzhen | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | LIU Qiang | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | 江波 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | 姜立平 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | 吴美羔 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | 王晓光 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | 陈子齐 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China | | 姜恩海 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College.Tianjin 200020, China |
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| Abstract:: |
| Objective The therapeutic effect of rhGM-CSF and rhEPO was estimated in 3 patients with acute radiation sickness(ARS). Methods One patient of severe degree bone marrow form of ARS received rhGM-CSF and rhEPO treatments and other two patients of moderate degree were administered only with rhGM-CSF.The serum concentrations of GM-CSF and EPO were determined in all cases on days 10 and 79 after irradiation. Results when the patients were administered with rhGM-CSF,their peripheral blood leukocytes fell slowly and then rose again quickly,the duration of leucocytopenia was shortened,and bone marrow hematopoiesis recovered early.RhEPO could accelerate the recovery of reticulocyte.Erythroblast percentage in proliferation pool increased.The serum concentrations of GM-CSF and EPO were much higher in all cases at day 10,which correlated with the irradiation doses and the degrees of injury in hematopoietic tissues. Conclusion The therapy using rhGM-CSF and rhEPO could promote the hemapoietic recovery in these cases with moderate and severe dagree bone marrow form of ARS. |
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