| YANG Zhanshan,YANG Shuqin,ZHU Shoupeng.Effects of low doses 147Pm internal irradiation against hereditary mutation in mouse cells induced by high dose of radiation\[J].Chinese Journal of Radiological Medicine and Protection,2001,21(2):114-116 |
| Effects of low doses 147Pm internal irradiation against hereditary mutation in mouse cells induced by high dose of radiation\ |
| Received:August 20, 2000 |
| DOI： |
| KeyWords:147Pm Adaptive response mn PCE mn NCE Chromosome aberration |
| FundProject:国家核工业科学基金资助项目(71966201) |
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| Abstract:: |
| Objective To investigate the effects of low doses 147 Pm internal irradiation against hereditary mutation in mouse cells induced by subsequent high dose of 147 Pm irradiation. Methods The frequencies of micronucleated polychromatic erythrocytes (mn-PCE) micronucleated normochromatic erythrocytes (mn-NCE) and chromosome aberration in bone marrow and peripheral blood cells were observed. Results The frequencies of nm PCE、mn NCE and chromosome aberration induced by high dose of 147 Pm irradiation showed a highly significant increase over the control at 24 h after irradiation (P<0.05 or 0.01).However, the frequencies in cells pre exposed to 0.37- 37 Bq/g of 147 Pm were decreased significantly (P<0.05 or 0.01),as compared with those of the group without pre exposure. Conclusion Low doses of in vivo 147 Pm β-irradiation can induce a radioadaptive response of the lymphocytes and erythroblasts.The induction of the adaptive response has a wide dose range.The mn-PCE and mn-NCE are more sensitive indexes for revealing biological effects of radiation as compared with the chromosome aberration. |
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