| CHEN Honghong,HU Yuxing,WANG Yinghua,et al.Protective effects of catecholomic acid derivatives on radiation induced damage of rat liver mitochondria[J].Chinese Journal of Radiological Medicine and Protection,2001,21(2):111-113 |
| Protective effects of catecholomic acid derivatives on radiation induced damage of rat liver mitochondria |
| Received:May 11, 2000 |
| DOI： |
| KeyWords:Chelating agents Oxygen free radicals Mitochondria γ irradiation |
| FundProject:国家自然科学基金青年基金资助项目(39700039) |
| Author Name | Affiliation | | CHEN Honghong | Institute of Radiation Medicine, Medical Center of Fudan University, Shanghai 200032, China | | HU Yuxing | Institute of Radiation Medicine, Medical Center of Fudan University, Shanghai 200032, China | | WANG Yinghua | Institute of Radiation Medicine, Medical Center of Fudan University, Shanghai 200032, China | | 杨照华 | Institute of Radiation Medicine, Medical Center of Fudan University, Shanghai 200032, China | | 罗梅初 | Institute of Radiation Medicine, Medical Center of Fudan University, Shanghai 200032, China | | 孙梅贞 | Institute of Radiation Medicine, Medical Center of Fudan University, Shanghai 200032, China |
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| Abstract:: |
| Objective To evaluate the effects of catecholomic acid derivatives 9501,9502 and 7601 (CBMIDA) against radiation induced injury of rat liver mitochondria in vitro. Methods The injury of rat liver mitochondria was induced by γ-irradiation in vitro. The contents of MDA were assayed by spectrophotometry of TBA.The absorption value at 520 nm was measured to detect swelling of mitochondria.The electron microscopic samples of mitochondria were prepared. Results All 9501 (5×10-6 mol/L),9502(10-5 mol/L),and 7601(10-5 mol/L) significantly inhibited radiation induced increase of MDA information.The swelling of mitochondria induced by irradiation was also prevented by 9501,7601.The electron micrographs also showed that 9501 markedly reduced the pathological damage of mitochondria induced by γ-irradiation.The mechanisms of antioxidative action of catecholomic acid derivatives was discussed. Conclusion Injurious effect of radiation on rat liver mitochondria can be prevented by catecholomic acid derivatives 9501,9502 and 7601 (CBMIDA). |
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