| YANG Jianzheng,LIANG Shuo,QU Yaqin.Effects of low dose mitomycin C on experimental tumor radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2001,21(2):100-102 |
| Effects of low dose mitomycin C on experimental tumor radiotherapy |
| Received:July 21, 2000 |
| DOI： |
| KeyWords:Mitomycin C Tumor radiotherapy Adaptive response |
| FundProject:国家自然科学基金资助项目(39270236) |
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| Abstract:: |
| Objective To evaluate the possibility of low dose mitomycin C(MMC)as an adjuanct therapy for radiotherapy. Methods Change in tumor size tumor bearing mice was measured.Radioimmunoassay was used to determine immune function of mice. Results Low dose MMC’s pretreatment reduced tumor size more markedly than did radiotherapy only.The immune function in mice given with low dose MMC 12h before radiotherapy was obviously higher than that in mice subjected to radiotheraphy only(P<0.05),and was close to that in the tumor bearing mice before radiotherapy. Conclusion Low dose MMC could improve the radiotherapy effect.Pretreatment with low dose MMC could obviously improve the immune suppression state in mice caused by radiotherapy.The mechanism of its improvement of radiotherapeutic effect by low dose of MMC might be due to its enhancement of immune function and induction of adaptive response in tumor bearing mice. |
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