| SU Bingyin,CAI Wenqin,ZHANG Chenggang.60Coγirradiation enhances expression of GAP-43 mRNA in rat brain[J].Chinese Journal of Radiological Medicine and Protection,2001,21(2):80-82 |
| 60Coγirradiation enhances expression of GAP-43 mRNA in rat brain |
| Received:May 20, 2000 |
| DOI： |
| KeyWords:60Co γ-rays GAP43mRNA Rat Brain Nerve regeneration |
| FundProject:国家自然科学基金资助项目(39900078);全军95科研基金;重庆市应用基础研究课题 |
| Author Name | Affiliation | | SU Bingyin | Department of Histology &
Embryology, Third Military Medical University, Chongqing 400038, China | | CAI Wenqin | Department of Histology &
Embryology, Third Military Medical University, Chongqing 400038, China | | ZHANG Chenggang | Department of Histology &
Embryology, Third Military Medical University, Chongqing 400038, China | | Perbal. B | University Paris Ⅶ, Paris, France |
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| Abstract:: |
| Objective To study the relationship between the expression of GAP-43 mRNA and nerve regeneration in rat brain after 60Co γ-irradiation. Methods Wistar rats were subjected to wholebody irradiation with 8 Gy 60Co γ-rays.The expression of GAP-43 was detected by in situ hybridization histochemistry using DigcRNA probe. Results It was found that the expression of GAP-43 mRNA increased in the cerebral cortex,caudate,putamen,globus pallidus,thalamus and hypothalamus one week after 8 Gy 60Co γ-irradiation.The peak of GAP-43 mRNA expression was observed in the fourth week and then began to decrease but still remained at a higher than normal level.However,it decreased to a low level after 7 weeks. Conclusion Enhanced expression of GAP-43 mRNA after 60Co γ-irradiation in rat brain is associated with nerve regeneration and reconstruction of synapse. |
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