| HAO Jing,LUO Qingliang,XIONG Guolin.Therapeutic effect of rhIL-11 administered at different times on acute radiation sickness in rhesus monkeys[J].Chinese Journal of Radiological Medicine and Protection,2001,21(1):31-34 |
| Therapeutic effect of rhIL-11 administered at different times on acute radiation sickness in rhesus monkeys |
| Received:February 26, 2000 |
| DOI： |
| KeyWords:Acute radiation sickness Recombinant human interleukine11 Haemotopoietic facto |
| FundProject:全军“九五”指令性课题基金资助项目(9605001) |
| Author Name | Affiliation | | HAO Jing | Beijing Institute of Radiation Medicine, Beijing 100850, China | | LUO Qingliang | Beijing Institute of Radiation Medicine, Beijing 100850, China | | XIONG Guolin | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 柳晓兰 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 邱丽玲 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 陈国志 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 黄缨 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 葛平 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 耿煜 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 孙连生 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 董波 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 李元敏 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 陈望秋 | 医进生物技术(北京)有限公司 | | 沈纯 | 医进生物技术(北京)有限公司 |
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| Abstract:: |
| Objective This report describes the therapeutic effect of recombinant human interlukine-11(rhIL-11)administered at different times on acute radiation sickness in monkeys. Methods Rhesus monkeys irradiated with 3.0 Gy 60 Co γ-rays were divided into 3 groups.One group was the control administered with vehicle,the second one was subjected to administer rhIL-11 on days 0-13 after TBI(60 μg·kg -1 ·d -1 ,sc) and the third one to administer rhIL-11 on days 13-26 after TBI at the same doses. Results The early treated group had higher platelet nadirs compared with that of the other two.The duration of platelet and leukocyte numbers below 50% of their baseline values shortened significantly in animals treated with rhIL-11,especially in the early treated group.During the first week after irradiation,the early treated group had lower erythrocyte count compared with the control,but it began to rise at day 19 after irradiation.Semi-solid bone marrow cell culture demonstrated that rhIL-11 could stimulate bone marrow cells to form more CFU-MK,CFU-Mix,CFU-E,BFU-E and CFU-GM in vitro .We also got the same results in histopathological observation. Conclusion rhIL-11 administered at different times can not only accelerate the haemotopoietic recovery of acute radiation sickness in rhesus monkeys,but also result in better therapeutic effect when administered earlier. |
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