| WU Hong ying,LIU Peixun,YUE Jingyin.The effects of E838 on malignant transformation of mammalian cell induced by radiation[J].Chinese Journal of Radiological Medicine and Protection,2001,21(1):21-23 |
| The effects of E838 on malignant transformation of mammalian cell induced by radiation |
| Received:February 28, 2000 |
| DOI： |
| KeyWords:E838 Colony forming rate Transformation rate 137 Cs γ radiation |
| FundProject:中国医学科学院中国协和医科大学重点基金资助项目(9804) |
| Author Name | Affiliation | | WU Hong ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | LIU Peixun | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | YUE Jingyin | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | 宋永良 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | 穆传杰 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China |
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| Abstract:: |
| Objective To study the effects of an anti-radiation medicine E838 on malignant transformation of mammalian cell induced by radiation. Methods CHO and CHL cells were cultured in the RPMI 1640 medium with or without E838 and were irradiated with different doses of 137 Cs γ rays.The total number of colonies and type Ⅰ,Ⅱ and Ⅲ malignant transformation foci were counted for each group three weeks after irradiation. Results Statistic analysis indicated that the colony-forming rate of CHO cells in the groups cultured with E838(1 μg/ml) was significantly higher than that of groups without E838 after irradiation with 3 Gy 137 Cs γ-rays( P <0.05).The transformation rate of the group with E838 was lower than that of the group without( P <0.01).There was a similar tendency in CHL cells at the same irradiation dose,without statistical significance. Conclusion In the proper concentration range E838 shows certain inhibitory effects on malignant transformation of mammalian cells induced by radiation. |
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