| PENG Ruiyun,WANG Dewen,XIONG Chengqi.Studies on hematopoietic cell apoptosis and the relative gene expression in irradiated mouse bone marrow[J].Chinese Journal of Radiological Medicine and Protection,2001,21(1):19-20 |
| Studies on hematopoietic cell apoptosis and the relative gene expression in irradiated mouse bone marrow |
| Received:March 18, 2000 |
| DOI： |
| KeyWords:Radiation Bone marrow Apoptosis bcl2 p |
| FundProject:全军“九五”青年基金资助项目(98Q081) |
| Author Name | Affiliation | | PENG Ruiyun | Institute of Radiation Medicine, Beijing 100850, P.R.China | | WANG Dewen | Institute of Radiation Medicine, Beijing 100850, P.R.China | | XIONG Chengqi | Institute of Radiation Medicine, Beijing 100850, P.R.China | | 高亚兵 | Institute of Radiation Medicine, Beijing 100850, P.R.China | | 杨红 | Institute of Radiation Medicine, Beijing 100850, P.R.China | | 崔玉芳 | Institute of Radiation Medicine, Beijing 100850, P.R.China | | 汪宝珍 | Institute of Radiation Medicine, Beijing 100850, P.R.China |
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| Abstract:: |
| Objective To study apoptosis and expressions of bcl-2 and p53 in irradiated mouse bone marrow. Methods LACA mice were irradiated with 60 Co γ rays.By means of in situ terminal labeling, in situ hybridization and image analysis,the authors studied radiation-induced apoptosis of hematopoietic cells and the expressions of bcl-2 and p53. Results The characteristics of apoptosis appeared in hematopoietic cells at 6 hrs after irradiation.The expression of bcl-2 was obviously decreased when apoptosis of hematopoietic cells occurred,whereas it increased in the early recovery phasep53 protein increased during both apoptosis of hematopoietic cells and the recovery phase,and mutant type p53 DNA was positive only in the recovery phase. Conclusion Radiation may induced apoptosis of hematopoietic cells in a dose-dependent mannerBoth bcl-2 and p53 genes play an important role in apoptosis and recovery phase. |
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