| TIAN Qiong,YANG Lan,ZHANG Fake,et al.Protective effect of platelet factor 4 on acute hematopoietic radiation injury in mice and its mechanism[J].Chinese Journal of Radiological Medicine and Protection,2000,20(6):416-418 |
| Protective effect of platelet factor 4 on acute hematopoietic radiation injury in mice and its mechanism |
| Received:November 30, 1999 |
| DOI： |
| KeyWords:Platelete factor 4 Radiation injury Radioprotection |
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| Abstract:: |
| Objective To investigate the protective effect and mechanism of platelet factor 4(PF4)on irradiated mice. Methods One hundred male mice were randomized to several groups and exposed whole-bodily to 7 5 Gy 60Co γ rays.The mice were treated with injections of PF4(20 μg/kg to 60 μg/kg)twice at an interval of 6 h and 20 h, after the second injection they were irradiated.The 30-day survival rated were recorded. Results The 30-day survival rate and the mean survival days, bone marrow cellularity.DNA content of bone marrow cells, number of CFU-GM on agar culture, peripheral blood cells, spleen/body weight ratio and number of spleen colonie were all significantly higher in the PF4 treated groups than in the corresponding irradiated controls (P<0.01). Conclusion PF4 has beneficial protective effect on irradiated mice.Its mechanism could be relatied to protection of hematopoietic cells and accele ration of their recovery. |
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