| LI Huixiang,WANG Yaohe,SHI Yonggang.Study on relationship between apoptosis-related genes and radiosensitivity of esophageal squamous cell carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2000,20(6):411-413 |
| Study on relationship between apoptosis-related genes and radiosensitivity of esophageal squamous cell carcinoma |
| Received:September 21, 1999 |
| DOI： |
| KeyWords:Squamous cell carcinoma of esophagus Apoptosis-related gene Radiosensitivity |
| FundProject: |
| Author Name | Affiliation | | LI Huixiang | Department of Pathology, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450000, China | | WANG Yaohe | Department of Pathology, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450000, China | | SHI Yonggang | 河南医科大学附属一院放疗科 | | 高冬玲 | Department of Pathology, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450000, China | | 张云汉 | Department of Pathology, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450000, China |
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| Abstract:: |
| Objective To observing the relationship between apoptosis-ralated genes bcl-2, c-myc, p53 and the radiosensitivity of esophageel squamous cell carcinoma. Methods The expression levels of bcl-2, c-myc and p53 genes in 57 biopsy samples from patients of esophageal squamous cell carcinoma were detected with the LSAB immunohistochemistry method.All the patients were treated with radiotherapy.The radiotherapeutic effect in these patients was observed and the relation between gene expression and radiosensitivity was analyzed. Results Compared with the bcl-2-negative group, the radiosensitivity of bcl-2-positive one was lower(P<0.01).The radiosensitivity of p53-positive group was slightly lower than that of the p53-negative one (P<0.05).The c-myc protein expression was not related to radiosensitivity. Conclusion Detection and comprehensive analysis of bcl-2, c-myc and p53 protein expressions are useful in forecasting the radiotherapeutic effect on squamous cell carcinoma of esophagus. |
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