| GUO Dehuang,DONG Bo,LIU Nongle.The regulation of ras-raf signaling pathway on G1 phase of the irradiated cells[J].Chinese Journal of Radiological Medicine and Protection,2000,20(6):408-410 |
| The regulation of ras-raf signaling pathway on G1 phase of the irradiated cells |
| Received:April 04, 2000 |
| DOI： |
| KeyWords:Irradiation Cell cycle Cyclin |
| FundProject:军事医学科学院博士后基金资助项目(20101) |
| Author Name | Affiliation | | GUO Dehuang | Institute of Radiation Medicine, Beijing 100850, China
*Institute of Basic Medicine, Beijing 100850, China | | DONG Bo | Institute of Radiation Medicine, Beijing 100850, China
*Institute of Basic Medicine, Beijing 100850, China | | LIU Nongle | 北京基础医学研究所 | | 文耕云 | Institute of Radiation Medicine, Beijing 100850, China
*Institute of Basic Medicine, Beijing 100850, China | | 罗庆良 | Institute of Radiation Medicine, Beijing 100850, China
*Institute of Basic Medicine, Beijing 100850, China | | 毛秉智 | Institute of Radiation Medicine, Beijing 100850, China
*Institute of Basic Medicine, Beijing 100850, China |
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| Abstract:: |
| Objective To investigate the way of ras-raf signaling pathway which regulate the G1 phase in irradiated KG-1 cells. Methods Blocked the GM-CSF signaling pathway by transfected DN-ras and then momentary transfected cyclin D1 into irradiated KG-1 cells, the effects of cyclin D1 on G1 phase was examined. Results The irradiated KG-1 cells transfected DN-ras can't recover form G1 phase arrest even though the GM-CSF was given, momentary transfected cyclin D1 promote the irradiated KG-1 cells from G1 arrest. Conclusion Activation of ras-raf signaling pathway regulate the cell cycle of the irradiated KG-1 cells through promotion the expression of the cyclin D1. |
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