| LI Yi,WANG Haiqing,ZHOU Guangqing.Effect of scallop extract on repair of radiation damage[J].Chinese Journal of Radiological Medicine and Protection,2000,20(6):400-403 |
| Effect of scallop extract on repair of radiation damage |
| Received:January 20, 2000 |
| DOI： |
| KeyWords:L615/radiotherapy Scallop extract Radiation damage Repair effect |
| FundProject:山东省科委基金资助项目(鲁科技9550) |
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| Abstract:: |
| Objective To investigate the effects of combination of 192Ir-irradiation and scallop extract on antioxidative and immunological function in tumor-bearing mice and to understand the effect of the scallop extract on repair of radiation damage. Methods Tumor-bearing male L615 mice were subjected to 192Ir-irradiation.The mice of 192Ir-irradiation group were fed with scallop extract daily during the experiment. 192Ir-irradiation was started from fourteen days after cell inoculation.On the next day after the last 192Ir-irradiation, NK cell activity, the transformation strength induced by mitogens, spleen index, the glutathione peroxidase (GSH-Px)and superoxide dismutase (SOD) activities and the malondialdehyde(MDA)level were determined. Results The 192Ir-irradiation-caused decrease of immunological indicators increased markedly, including NK cell activity, the transformation strength induced by mitogens, spleen index.Moreover, 192Ir-irradiation caused decrease of GSH-Px and SOD activities and increase of MDA level in liver and blood all reversed significantly by scallop extract. Conclusion The combination of 192Ir-irradiation and scallop extract can enhance antioxidation ability and immunological function of tumor-bearing mice in radiotherapy and promote repair of radiation damage. |
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