| GAO Linlu,CUI Yufang,YANG Hong.Pathomorphology of spleen lymphocyte apoptosis in large dose 60Co γ-irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2000,20(5):327-329 |
| Pathomorphology of spleen lymphocyte apoptosis in large dose 60Co γ-irradiated mice |
| Received:December 15, 1999 |
| DOI： |
| KeyWords:Radiation Spleen lymphocyte Pathomorphology Apoptosis |
| FundProject: |
| Author Name | Affiliation | | GAO Linlu | Institute of Radiation Medicine, Beijing 100850, China | | CUI Yufang | Institute of Radiation Medicine, Beijing 100850, China | | YANG Hong | Institute of Radiation Medicine, Beijing 100850, China | | 夏国伟 | Institute of Radiation Medicine, Beijing 100850, China | | 彭瑞云 | Institute of Radiation Medicine, Beijing 100850, China | | 高亚兵 | Institute of Radiation Medicine, Beijing 100850, China | | 王德文 | Institute of Radiation Medicine, Beijing 100850, China |
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| Abstract:: |
| Objective The aim of this study was to investigate the pathomorphological changes of spleen lymphocyte apoptosis after 60 Co γ-irradiation. Methods The mice were irradiated with 6,9,12,15 and 20 Gy of 60 Co γ-rays. At different times after irradiation,the mice were sacrificed and the pathological changes of spleen lymphocyte were observed by light and transmission electron microscopies. Results Spleen lymphocyte decreased evidently and the peak of apoptosis in spleen lymphocyte was dependent on radiation dose and the time after irradiation. Conclusion After γ-irradiation with large doses,pathological changes of spleen lymphocyte apoptosis in mice can be divided into obviously different stages. The main causes of death of spleen lymphocytes are different in different dose groups. |
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