| GAO Ying,QI Shuling,YANG Fengtong,et al.Effects of prenatal irradiation on the functions of murine haematopoietic stromal cells[J].Chinese Journal of Radiological Medicine and Protection,2000,20(5):324-326 |
| Effects of prenatal irradiation on the functions of murine haematopoietic stromal cells |
| Received:December 11, 1999 |
| DOI： |
| KeyWords:Long-term effects of radiation Bone marrow stromal cells GM-CSF SCF CFU-GM |
| FundProject:国家自然科学基金资助项目(39770192) |
| Author Name | Affiliation | | GAO Ying | Institute of Hematology, CAMS and PUMC, Tianjin, 300020, China | | QI Shuling | Institute of Hematology, CAMS and PUMC, Tianjin, 300020, China | | YANG Fengtong | 中国医学科学院中国协和医科大学放射医学研究所 | | 张宇光 | 中国医学科学院中国协和医科大学放射医学研究所 | | 王映兰 | 中国医学科学院中国协和医科大学放射医学研究所 | | 刘杰文 | Institute of Hematology, CAMS and PUMC, Tianjin, 300020, China |
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| Abstract:: |
| Objective To observe the effects of prenatal irradiation on functions of haematopoietic stromal cells. Methods Long-term effects of 2.0Gy 137 Cs γ-radiation at midterm gestation of mice on the haematopoietic stromal cells of their offspring were studied. Results The quantity of femoral bone marrow nucleated cells (BMNCs) in the irradiated offspring was markedly lower than that of the normal offspring (P <0.01).And stromal expressions of the growth factors,granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem cell factor (SCF),of the irradiated offspring were higher compared with those of the normal offspring (P<0.05 ).At the same time,the ability to support heamatopoiesis by the stromal cells in irradiated offspring was higher than that in normal offspring. Conclusion The results suggest that irradiation with 2.0Gy 137 Cs γ-rays is sufficient to produce measurable effects on developing murine haematopoietic stromal cells. |
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