| WAHG Yuexing,ZHANG Hongyuan,WANG Lanjin.Research on biological effects induced by γ-irradiation combined with benzene, toluene and carbon monoxide inhalation[J].Chinese Journal of Radiological Medicine and Protection,2000,20(5):301-305 |
| Research on biological effects induced by γ-irradiation combined with benzene, toluene and carbon monoxide inhalation |
| Received:June 07, 1998 |
| DOI： |
| KeyWords:rays Benzene Toluene CO Biological effect Interaction |
| FundProject:国防科工委重点资助项目(9.2.6②) |
| Author Name | Affiliation | | WAHG Yuexing | Naval Medical Research Institute, Shanghai 200433, China | | ZHANG Hongyuan | Naval Medical Research Institute, Shanghai 200433, China | | WANG Lanjin | Naval Medical Research Institute, Shanghai 200433, China | | 潘燕 | Naval Medical Research Institute, Shanghai 200433, China | | 范正平 | Naval Medical Research Institute, Shanghai 200433, China |
|
| Hits: 2609 |
| Download times: 1740 |
| Abstract:: |
| Objective To explore the patterns of bilogical effects induced by γ-rays irradiation combined with slmultaneous inhalation benzene,toluene or carbon monoxide and to analyze their antagonistic,additive or synergistic interaction. Methods Ninety healthy male rabbits were equally divided into 9 groups.Eight of which were asigned to be test groups according to four-factor-two-dose-level orthogonal layout ｛L 8(2 7)｝ program and the other one was the control group.The two dose-levels of these four agents were:the γ-irradiation doses were 0.0075 Gy/d and 0.0375Gy/d,and the two concentrations of benzene,toluene and carbon monoxide were 40±15 and 162±33 mg/m 3,90±30 and 407±68 mg/m 3,93±4 and 278±8 mg/m 3,respectively.The animals were exposed to γ-irradiation combined with benzene,toluene or CO vapour 2 h a day and 5 days a week for successive 8 weeks.Variance analysis and comparison between test groups were made for analyzing the test data. Results (1)It was showed that γ-irradiation,benzene and toluene could all induce chromosome aberrations,SCEs and micronuclei of lymphocytes and chromosome aberrations of bone marrow cells;but no effect could be seen in CO alone treated group.(2)The ratios (ω) of biological effects jointly induced by the four agents and the sum of those induced separately by them were 2.16,1.58,2.07,2.67,1.25 and 1.18 for dicentric+ring,acentric,aberration cells,total aberration,micronuclei and micronucleus cells,respectively,and it was as high as 5.97 for aberrant sperms.The ratios showed that the interactions were synergistic(ω>1).However,interactions between γ-rays and benzene was antagonistic for acentric of lymphocytes.(3)The four agents could all obviously cause decrease of weight index of testis,γ-rays,toluene and CO could all markedly reduce the number of sperms and increase the ratio of aberrant sperms. Conclusion γ-irradiation combined with benzene,toluene and CO inhalation can lead to significant interactions which are mainly synergistic,while CO can cause obvious effects on sex gland when it is combined with γ-rays,benzene and toluene. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
