| WANG Jixian,YU Wenru,LI Benxiao,et al.Relationship between mutation frequency of GPA locus and cumulative dose among medical diagnostic X-ray workers[J].Chinese Journal of Radiological Medicine and Protection,2000,20(4):282-285 |
| Relationship between mutation frequency of GPA locus and cumulative dose among medical diagnostic X-ray workers |
| Received:September 18, 1999 |
| DOI： |
| KeyWords:Medical diagnostic X-ray workers GPA focus mutation assay Biodosimeter |
| FundProject:国家自然科学基金资助项目(39470228) |
| Author Name | Affiliation | | WANG Jixian | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | YU Wenru | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | LI Benxiao | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 樊体强 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 李征 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 高智伟 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 陈振军 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 赵永成 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China |
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| Abstract:: |
| Objective To explore the feasibility of using GPAlocus mutation assay as a biodosimeter for occupational exposure to ionizing radiation. Methods An improved technique of GPAlocus mutation assay was used in the study.The frequencies of mutant RBCin peripheral blood of 55 medical Xray workers and 50 controls employed in different calendar-year periods were detected.The relationship between mutation frequencies (MFs) and period of entry, working years and cumulative doses were analyzed. Results The MFs were significantly elevated among Xray workers employed before 1970.This finding is similar to the result of cancer epidemiological study among medical Xray workers, in which the cancer risk was significantly increased only Xray workers employed before 1970.The MFs of GPAincreased with increasing cumulative dose.The dose-effect relationship of NΦMF with cumulative dose was closer than that of NΦMF. Conclusion There are many problems to be solved for using GPA MF assay as a biodosimeter such as individual variation, specificity and calibration curve of dose-effect relationship. |
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