| LIU Yongbao,RAO Yongqing,XU Luxi.Effects of 60Coγ-radiation on brain hippocampal tissue of adult mice[J].Chinese Journal of Radiological Medicine and Protection,2000,20(4):267-270 |
| Effects of 60Coγ-radiation on brain hippocampal tissue of adult mice |
| Received:October 13, 1999 |
| DOI： |
| KeyWords:Hippocampus Mice Ionizing radiation Neuropathology |
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| Abstract:: |
| Objective To study neuropathological changes of hippocampus tissue in adult mice following a series of irradiation with 60Co γ-rays.Methods Male mice of Kunming strain in experimental group( n =8)were exposed total bodily to 60Co γ-rays at 2.0 Gy once every two days. Ahistopathological imaging analysis of the mouse brain tissue was carried out after paraffin embedding and a series of sections were made and stained with Nissl and Weil staining methods. Results In the irradiation group (the cumulative dose=26 Gy) loss of pyramidal cells in hippocampus was significant when compared with the control group. Neuropathological changes were characterised by reduced neuron size, nuclear pyknosis and karyolysis. The neurofibrillar density of the pyramidal layer in the irradiation group was much lower than that of the control group ( P<001).Susceptibilities of the four subzones to the radiation appeared following order of CA1>CA2>CA3>CA4 in the hippocampus.Conclusion The neuronal damage in hippocampus after 60Co irradiation could form a pathological basis in reduction of memorial and learning ability. |
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