CUI Xiaoli,XU Bo,YU Zhentao,et al.Fractionated radiosensitization of murine tumor and normal tissue by carbogen plus low concentration oxygen radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2000,20(4):261-163 |
Fractionated radiosensitization of murine tumor and normal tissue by carbogen plus low concentration oxygen radiotherapy |
Received:January 30, 2000 |
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KeyWords:Carbogen plus low concentration oxygen radiotherapy Fractionated schedule Therapeutic gain factor |
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Abstract:: |
Objective To Study the dose response relationships of murine tumor and normal tissue in fractionated carbogen plus low concentration oxygen radiotherapy (CPLCOR).Methods The experiments included three groups: air, carbogen (95%O2+5%CO2), and carbogen plus low concentration oxygen (10%O2+85%N2+5%CO2), five fractions were given to animals using a biological equivalence dose formula. The transplantable spontaneous tumor LA759 in inbred T739 mice was used for tumor response studies and the skin radiation reaction was evaluated with Douglas and Fowler grading method. Results In fractionated schedule, the sensitivity enhancement ratios (SER) were 1.34 and 1.64 for CPLCORand carbogen alone groups respectively. In skin response, the CPLCORgroup showed a relatively milder reaction than the carbogen group did: their SERwere 1.19 and 1.49 and the therapeutic gain factors (TGFs) for fractionated schedule were 1.13 and 1.10 respectively. Conclusions Compared with the results of single dose studies, TGFdecreases during fractionated irradiation, indicating that the CPLCORhas fewer advantage than carbogen radiotherapy. |
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