CUI Xiaoli,XU Bo,YU Zhentao,et al.Fractionated radiosensitization of murine tumor and normal tissue by carbogen plus low concentration oxygen radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2000,20(4):261-163
Fractionated radiosensitization of murine tumor and normal tissue by carbogen plus low concentration oxygen radiotherapy
Received:January 30, 2000  
DOI:
KeyWords:Carbogen plus low concentration oxygen radiotherapy  Fractionated schedule  Therapeutic gain factor
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Author NameAffiliation
CUI Xiaoli 300060, 天津医科大学附属肿瘤医院 
XU Bo 中国医学科学院中国协和医科大学肿瘤医院 
YU Zhentao 300060, 天津医科大学附属肿瘤医院 
沈瑜 中国医学科学院中国协和医科大学肿瘤医院 
王争 中国医学科学院中国协和医科大学肿瘤医院 
殷蔚伯 中国医学科学院中国协和医科大学肿瘤医院 
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Abstract::
      Objective To Study the dose response relationships of murine tumor and normal tissue in fractionated carbogen plus low concentration oxygen radiotherapy (CPLCOR).Methods The experiments included three groups: air, carbogen (95%O2+5%CO2), and carbogen plus low concentration oxygen (10%O2+85%N2+5%CO2), five fractions were given to animals using a biological equivalence dose formula. The transplantable spontaneous tumor LA759 in inbred T739 mice was used for tumor response studies and the skin radiation reaction was evaluated with Douglas and Fowler grading method. Results In fractionated schedule, the sensitivity enhancement ratios (SER) were 1.34 and 1.64 for CPLCORand carbogen alone groups respectively. In skin response, the CPLCORgroup showed a relatively milder reaction than the carbogen group did: their SERwere 1.19 and 1.49 and the therapeutic gain factors (TGFs) for fractionated schedule were 1.13 and 1.10 respectively. Conclusions Compared with the results of single dose studies, TGFdecreases during fractionated irradiation, indicating that the CPLCORhas fewer advantage than carbogen radiotherapy.
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