SUN Yimin,LIU Shuzheng.Effect of whole body X irradiation on production of nitric oxide in peritoneal macrophages of mice[J].Chinese Journal of Radiological Medicine and Protection,2000,20(4):232-234
Effect of whole body X irradiation on production of nitric oxide in peritoneal macrophages of mice
Received:October 29, 1999  
DOI：
KeyWords:Irradiation  Macrophages  Induced nitric oxide synthase  Nitric oxide
FundProject:国家自然科学基金资助项目(39570188)
Author NameAffiliation
SUN Yimin MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China 
LIU Shuzheng MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China 
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Abstract::
      Objective To disclose the changes of nitric oxide (NO) in murine peritoneal macrophages at different time intervals after whole body irradiation (WBI) with 75 mGy and 2.0 Gy X-rays and the changes of NOand induced nitric oxide synthase (iNOS)24 hours after WBIwith 0.05-6.0 Gy X-rays. Methods Immunohistochemistry and spectophotometry were used. Results The expression of iNOSand the production of NOincreased in a dose-dependent manner after irradiation.The production of NOincreased from 6h to 48h and reached its peak at 48h, which was 3.8-fold of sham-irradiated controls. Conclusion Ionizing radiation stimulates expression of iNOSand production of NOin peritoneal macrophages of mice.
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