| ZHANG Hao,MAO Bingzhi,DONG Bo.Synergistic effect of IL-6 combined with G-CSF on hematological function in irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2000,20(3):171-175 |
| Synergistic effect of IL-6 combined with G-CSF on hematological function in irradiated mice |
| Received:October 18, 1999 |
| DOI： |
| KeyWords:Cytokine GCSF IL6 Irradiation |
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| Abstract:: |
| Objective To investigate the synergisitic effects and mechanism of IL-6 combined with GCSF on hematological function in irradiated mice. Methods The numbers of RBC, WBC, PLT and HGB were counted by F-800apparatus.The numbers of CFU-GM and CFUS were counted by usual method.The programmed cell death was assayed by agarose electrophoresis. Results IL-6 combined with GCSF could accelerate the recovery of peripheral blood, promote the recovery of endogenous CFUS, and increase the number of bone marrow cells and stimulate the formation of GM-CFU of bone marrow cells.It could raise survival rate of irradiated mice. Conclusion The synergistic effect of IL-6 combined with GCSF is better than that of either one. The mechanism of the effect is due to accelerative action on the recovery of residual bone marrow stem cells in irradiated mice.This procedure requires long time, and is not attributed to the inhibitory effect upon programmed cell death of bone marrow cells. |
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