| LI Xiujuan,HE Ronghua,LI Xinyi,et al.Influence of adaptative response to low dose radiation on radiation induced thymic lymphoma in mice[J].Chinese Journal of Radiological Medicine and Protection,2000,20(3):153-156 |
| Influence of adaptative response to low dose radiation on radiation induced thymic lymphoma in mice |
| Received:November 18, 1998 |
| DOI： |
| KeyWords:Low dose radiation Carcinogenic dose radiation Thymic lymphoma Immune functions |
| FundProject:国家自然科学基金资助项目(39670190) |
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| Abstract:: |
| Objective To search for influence of low dose radiation (LDR) on thymic lymphoma (TL) induced by carcinogenic dose radiation in C57BL/6J mice and its immunologic mechanism. Methods The model was adopted that C57BL/6J mice were subjected to whole body irradiation with 1.75 Gy Xray once every week for 4 weeks to induce TL.The incidence of TL was observed by microscopy 6 months after irradiation.The following indexes were examined:splenic NK cytotoxic activity, IL-2 and γ-IFN secretion activity.peritoneal macrophagic phagocytosis and its TNFα secretion activity the changes of thymocytedifferentiation in mice irradiated withdifferent dose 1 month after irradiation. Results The incidence ofTL in mice irradiated with 25mGy or 75mGy 6h or 12h before 1.75Gy irradiation were all lower than thatin mice irradiated with 1.75Gy only and it is more obvious in mice irradiated with 75mGy prior to car-cinogenic dose radiation. Immune parameters mentioned above in mice irradiated with 75mGy 12h before1.75Gy were higher than those in mice irradiated with 1.75 only and the majority approached to those of the sham-irradiated mice. The number of thymic CD4-CD8 cells or CD4-CD8-cells was lower andCD4+CD8+cells was higher in miceirradiatedwith 75mGy 12h before 1.75Gy than that in mice irradiat-ed with 1 .75Gy only. Conclusion LDR can induce the adaptative esponse of radiation-induced TL, andprevent or reduce the onset of radiation-induced TL.The suppression mechanism may be related to the im-munoenhancement effect and the adaptive response induced by LDR, decreasing immune function damage used by carcinogenic dose radiation eliminating thymic prelymphoma cells before they from solid tumor. |
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