| GU Qingyang,WANG Dewen,GAO Yabing.Pathological study on regularity of wound healing in rats irradiated with γ-rays before or after suffering trauma[J].Chinese Journal of Radiological Medicine and Protection,2000,20(2):94-97 |
| Pathological study on regularity of wound healing in rats irradiated with γ-rays before or after suffering trauma |
| Received:April 04, 1999 |
| DOI： |
| KeyWords:Irradiation Wound healing Rats Collagen Comparative analysis |
| FundProject:九五全军重点招标课题(96Z008) |
| Author Name | Affiliation | | GU Qingyang | Institute of Radiation Medicine, Beijing 100850, China | | WANG Dewen | Institute of Radiation Medicine, Beijing 100850, China | | GAO Yabing | Institute of Radiation Medicine, Beijing 100850, China | | 崔彩彬 | Institute of Radiation Medicine, Beijing 100850, China | | 夏国伟 | Institute of Radiation Medicine, Beijing 100850, China | | 崔雪梅 | Institute of Radiation Medicine, Beijing 100850, China | | 熊呈琦 | Institute of Radiation Medicine, Beijing 100850, China |
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| Abstract:: |
| Objective To study the different effects of radiation on wound healing in rats irradiated with γ-rays before or after suffering trauma. Methods Animal models of wound healing were set up,and they were locally irradiated before or after suffering trauma.The pathological changes were studied by gross and microscopic examinations.Immunohistochemistry and in situ hybridization were performed to detect the expression of collagen types Ⅰ and Ⅲ. Results Wound healing was impaired and delayed obviously in rats locally irradiated with 15 Gy in the time period betwecn 2 days before and 7 days after receiving trauma.The strongest effect was observed in rats irradiated immediately after trauma.Irradiation given on day 3 after trauma and day 2 before trauma resulted in moderate effects,while the least effect was noted in rats irradiated on day 7 after trauma. Conclusion The effect of radiation on wound healing depends on the time of irradiation before or after receiving trauma. |
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