| TIAN Ye,BAO Siyao,LIU Chunfeng.Apoptosis and morphological changes in hippocampus of rat brain after hemisphere irradiation[J].Chinese Journal of Radiological Medicine and Protection,2000,20(2):84-86 |
| Apoptosis and morphological changes in hippocampus of rat brain after hemisphere irradiation |
| Received:April 13, 1999 |
| DOI： |
| KeyWords:Ionizing radiation Hippocampus Apoptosis bcl-2 Morphological changes |
| FundProject:国家国防科工委项目(6920062-14) |
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| Abstract:: |
| Objective To study the apoptosis,the expression of bc1-2 and the morphological changes of various tissue components in the rat hippocampus after hemisphere irradiation. Methods The DNA contents and the quantities of bc1-2 protein were analyzed by flow cytometry.The histological sections were examined by electron and light microscopy.Results The apoptosis of hippocampal cells in the irradiated brain increased in most of the rats,the expression of bc1-2 decreased in the meantime,and those changes were significant only in the groups irradiated within 1 month.Necrosis was observed in some of the 30 Gy-3-month-period group. Different levels of morphological changes in blood vessels,neuroglia cells and neurons were found in rats of all other groups. Conclusion After hemisphere irradiation,apoptosis increases,bc1-2 protein decreases,and various components in the hippocampus change.These data suggest a possible association between the damage of various componens and development of radiation-induced brain toxicity. |
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