| LIU Wei,HOU Dianjun,QIAO Jianwei.Influence of low dose ionizing radiation on amplification and antitumor activity of LAK/TIL cells[J].Chinese Journal of Radiological Medicine and Protection,2000,20(1):40-42 |
| Influence of low dose ionizing radiation on amplification and antitumor activity of LAK/TIL cells |
| Received:February 08, 1999 |
| DOI： |
| KeyWords:Low dose Ionizing radiation LAK/TIL cells Amplification Cytotoxicity |
| FundProject:山东省科委基金资助项目[(94)197] |
| Author Name | Affiliation | | LIU Wei | Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | HOU Dianjun | Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | QIAO Jianwei | Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | 商希梅 | Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | 李洁清 | Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China |
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| Abstract:: |
| Objective To study the influence of low dose ionization on amplification and antitumor activity of LAK/TIL cells. Methods TIL cells isolated from Lewis lung cancer tissues and LAK cells from spleen of tumor bearing mouse were irradiated with different low doses of X rays and were cultured after irradiation. Results Low dose ionizing radiation improved the amplification volume of LAK/TIL cells,decreased the cell death ratio in amplification process,and increased the toxicity of LAK/TIL cells. Conclusions Low dose ionizing radiation can result in amplification of biologically activated lymphocytes,and decreases the death ratio of the cells in amplification process. |
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