| CHEN Guanying,GONG Manli,LU Jia.Therapeutic effect of G3 in rhesus monkeys with bone marrow form acute radiation sickness[J].Chinese Journal of Radiological Medicine and Protection,1999,19(6):375-378 |
| Therapeutic effect of G3 in rhesus monkeys with bone marrow form acute radiation sickness |
| Received:August 14, 1998 Revised:April 12, 1998 |
| DOI： |
| KeyWords:G3(rhGM CSF/rhIL3 F.P) Rhesus monkeys Bone marrow form acute radiation sickness Therapeutic effect |
| FundProject: |
| Author Name | Affiliation | | CHEN Guanying | Department of Radiation Medicine, Beijing Medical University, Beijing 100083, China | | GONG Manli | Department of Radiation Medicine, Beijing Medical University, Beijing 100083, China | | LU Jia | Department of Radiation Medicine, Beijing Medical University, Beijing 100083, China | | 赵慧云 | Department of Radiation Medicine, Beijing Medical University, Beijing 100083, China | | 沈钦剑 | Department of Radiation Medicine, Beijing Medical University, Beijing 100083, China | | 周梅 | Department of Radiation Medicine, Beijing Medical University, Beijing 100083, China |
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| Abstract:: |
| Objective To explore the effect of G3 (rhGM-CSF/rhIL3 F.P) on increasing the numbers of leukocytes and platelets in rhesus monkeys with bone marrow form acute radiation sickness. Methods Twenty normal rhesus monkeys were subjected to 4.0 Gy total body irradiation(TBI) and randomly divided into four groups (5 each).In the experimental groups G3 40 or 20μg/kg/d was subcutaneously(s.c.) injected for 20 days,whereas in the control group.Leucomax(GM-CSF) at 20μg/kg/d was s.c. injected for 20 days. Results The nadir and recovering peak values of WBC,ANC and PLT in the groups with G3 were markedly higher compared with those of the control group.G3 was effective in reducing the periods of low level WBC,ANC and PLT. Conclusion G3 can distinctly increase the numbers of WBC,ANC and PLT,and decrease haemorrhage and infection in myelosuppressed rhesus monkeys. |
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