| JU Guizhi,SU Xu,FU Haiqing.Immunological adaptive response induced by low dose radiation[J].Chinese Journal of Radiological Medicine and Protection,1999,19(6):369-371 |
| Immunological adaptive response induced by low dose radiation |
| Received:June 07, 1998 Revised:September 10, 1998 |
| DOI： |
| KeyWords:Low dose radiation Immunological adaptive response |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | JU Guizhi | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | SU Xu | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | FU Haiqing | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 罗灿 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 宋春华 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 范冰 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 刘林林 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 齐进 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 张迎春 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 刘建香 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 傅士波 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 龚守良 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 刘树铮 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China |
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| Abstract:: |
| Objective To investigate whether immunological adaptive response could be induced by low dose radiation. Methods The following techniques were employed in this experiment:3H-TdR incorporation for lymphocyte proliferation,a bioassay with CTLL cells for IL-2 activity,flow cytometry (FCM) for subsets and receptor expression of lymphocytes by their immunofluorescence stained with monoclonal antibodies,PI staining and FCM for cell cycle and apoptosis,sandwicHELISA for sIL-2R,fura-2AM loading for [Ca2+]i,and a formula for doubling time of cells in culture. Results Suppressive effects of immune functions by challenge dose could be reduced by low dose pre irradiation. Conclusion Multiple immunological adaptive responses could be induced by low dose radiation. |
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