| YU Yonghua,CHEN Yantiao,YU Jinming.A clinical study of radiosensitizing effect of irrisquinone combined with radiotherapy in esophageal cancer[J].Chinese Journal of Radiological Medicine and Protection,1999,19(5):313-315 |
| A clinical study of radiosensitizing effect of irrisquinone combined with radiotherapy in esophageal cancer |
| Received:February 11, 1998 Revised:August 11, 1998 |
| DOI： |
| KeyWords:Irrisquinones Esophageal carcinoma Radiotherapy Radiosensitizer |
| FundProject:山东省科委自然科学基金 |
| Author Name | Affiliation | | YU Yonghua | Shandong Tumor Hospital, Jinan 250117, China | | CHEN Yantiao | Shandong Tumor Hospital, Jinan 250117, China | | YU Jinming | Shandong Tumor Hospital, Jinan 250117, China | | 梁超前 | Shandong Tumor Hospital, Jinan 250117, China | | 孙新东 | Shandong Tumor Hospital, Jinan 250117, China | | 田世禹 | Shandong Tumor Hospital, Jinan 250117, China | | 韩俊庆 | Shandong Tumor Hospital, Jinan 250117, China | | 李建彬 | Shandong Tumor Hospital, Jinan 250117, China |
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| Abstract:: |
| Objective To observe the radiosensitization and side effects of irrisquinones in combination with radiotherapy in treatment of esophageal cancer. Methods From January 1996 to August 1997, 60 cases of esophageal cancer were randomly divided into two groups——the trial group (irisquinone plus irradiation, 30 cases) and the control group(radiotherapy alone, 30 cases).In the trial group, irisquinone provided by Shangdong Xinhua Pharmaceutical Factory was administered at 220mg/m2/day (110mg/m2, twice daily), in combination with radiotherapy throughout the course of treatment.Irradiation was administered with 1.25 MeV 60 Coγ rays and /or 6MV or 15MV X rays, 2 Gy per day and 5 times per week.Total dose was about 60-70 Gy over 6-7 weeks, and the median doses to the trial group and the control group were 66.1 Gy and 68.6 Gy, respectively. Results At the end of treatment course, complete remission rate(CR) in the trial group was 53.33% whereas that in the control group was 26.67% ( P< 0.05), and three months later, the CR were 73.33% and 46.67%, respectively.Sensitization ratios of irrisquinones were 1.68 and 1.27 by the the partial remission at doses of 40 Gy and 60 Gy.The acute toxicity of irrisquinones were diarrhea, nausea and vomiting.The diarrhea rate was 56.6% in the trial group which was higher than that in the control group, but it was generally not severe and the patients were adapted to it soon without interruption of its administration. Conclusion Irrisquinones in combination with radiotherapy in treatment of esophageal cancer can increase the complete remission rate at the end of treatment course. |
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