| ZHU Shoupeng,XIAO Dong,HAN Xiaofeng.DNA gel electrophoretic and microautoradiographic studies on apoptosis in bone tumor cells after exposure to 153 Sm|EDTMP[J].Chinese Journal of Radiological Medicine and Protection,1999,19(5):307-309 |
| DNA gel electrophoretic and microautoradiographic studies on apoptosis in bone tumor cells after exposure to 153 Sm|EDTMP |
| Received:May 15, 1998 Revised:October 20, 1998 |
| DOI： |
| KeyWords:DNA gel electrophoresis Microautoradiography 153 Sm-EDTMP Internal irradiation Bone tumor cells Apoptosis |
| FundProject:国际原子能机构资助 |
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| Abstract:: |
| Objective To study the characteristics of injury in apoptotic bone tumor cells and behavior of radionuclide 153Sm in tumor cells. Methods DNA gel electrophoresis and microautoradiographic tracing of apoptotic bone tumor cells at different intervals after 153Sm-EDTMP internal irradiation. Results Bone tumor cells internally irradiated with 153 Sm-EDTMP displayed characteristics of DNA ladder formation in apoptotic cells. 153 Sm could permeate through tumor cell membrane and be phagocytized by the tumor cells, showing membrane-seeking and membrane bounded apoptotic bodies condensation. Conclusion Progression of apoptosis in bone tumor cells induced by 153 Sm-EDTMP is dependent on the time elapse of 153 Sm internal irradiation. |
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