| YUAN Xiong,YE Changqing,LU Xiuqin,et al.Mutation of human bronchial epithelial cells induced by heavy ions[J].Chinese Journal of Radiological Medicine and Protection,1999,19(5):300-302 |
| Mutation of human bronchial epithelial cells induced by heavy ions |
| Received:October 08, 1998 Revised:April 11, 1999 |
| DOI： |
| KeyWords:hprt Mutation Heavy ions LET Cross section mutation |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| Objective To observe the mutation characteristic of human bronchial epithelial cell line induced by heavy ions. Methods The human bronchial epithelium cell line(BEAS-2B)was irradiated by heavy particle beams of Li, C, and F from an HI-13 tandem accelerator with the designed dose ranging from 0.5Gy～6.0 Gy, and their hprt mutation was analyzed. Results The fitted dose dependent linear equations for three categories of heavy ions were MF=1.63×10-5 D(Li), MF=8.64×10-5 D(C)and MF=1.33×10-5 D(F) respectivelyhere the dimension of dose is Gy.The RBEs were 1.27, 6.78, and 1.04 for Li, C and F, respectively, compared with γ ray irradiation.All the frequencies of hprt mutant have also shown positive linearity with fluence. Finally, the cross sections of mutation (σ-m, 10-4 μm2) and the mutagenicity(σ m/σ i, 10-5 )for Li, C and F, were 2.61, 41.5, 21.3 and 2.08, 10.2, 2.78 respectively. Conclusion The frequencies of cell mutation increase with the dose and there seems to be LET dependence. |
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