| LI Xiaoming,TONG Xin,SONG Tianbao,et al.Expression of caspase 3 gene in apoptotic HL 60 cell and different human tumor cell lines[J].Chinese Journal of Radiological Medicine and Protection,1999,19(5):297-299 |
| Expression of caspase 3 gene in apoptotic HL 60 cell and different human tumor cell lines |
| Received:September 17, 1998 Revised:January 22, 1999 |
| DOI： |
| KeyWords:radiation Apoptosis Caspase-3 Gene expression |
| FundProject:国家自然科学基金 |
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| Abstract:: |
| Objective To research the expression of caspase-3 gene in the apoptotic and the control HL-60 cells and in the different human tumor cell lines. Methods Caspase-3 mRNA in the control and γ radiation induced apoptotic HL-60 cells, and in the 6 types of human tumor cell lines, was analysed by Northern blot. Results The caspase-3 gene transcript was more highly expressed in leukemia cells HL-60, CEM, K562 and neuroblastoma SH-SY5Y than in cervical adenocarcinoma HeLa and breast carcinoma MCF7, and more highly in the radiation induced apoptotic HL-60 than in the control HL-60 cells. Conclusion The high level of expression of caspase-3 may aid the efforts to understand the tumor cell sensitivity to radiation, apoptosis and its inherent ability to survive. |
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