| ZHOU Xiangyan,WANG Bing,GAO Weimin.Threshold dose to developing central nerve system of rats and mice from prenatal exposure to tritiated water[J].Chinese Journal of Radiological Medicine and Protection,1999,19(4):254-257 |
| Threshold dose to developing central nerve system of rats and mice from prenatal exposure to tritiated water |
| Received:March 22, 1999 Revised:May 04, 1999 |
| DOI： |
| KeyWords:Tritiated water Rats Mice Central nerve system Hippocampus Ca2+ conductance Threshold dose |
| FundProject:国家自然科学基金;卫生部医学研究基金 |
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| Abstract:: |
| Objective sTo study the threshold dose to the developing central nerve system of rats and mice from prenatal exposure to tritiated water. Methods Pregnant adult C57BL/6J strain mice and Wistar strain rats were irradiated with betarays from HTO by a single intraperitoneal injection on the 12.5th and 13th days of gestation.The activities of HTO were 24.09, 48.18 and 144.54 (104Bq/g bw), respectively.Fiftysix parameters including postnatal growth, neurobehavior, pathology of brain, neuropeptide contents, changes of hippocampal neurons, Ca2+ conductance of hippocampal neurons etc were used to test the teratogenic threshold dose (the lowest dose was different from that of the control). Results Of the observed 56 parameters of rats and mice 804% indicated that the threshold doses for prenatal HTO exposure ranged from 0.030 Gy to 0.092 Gy, and the other 19.6% showed the threshold doses from 0.093 to 0.300 Gy. Conclusions There exists threshold dose from the low level tritiated water irradiation of the developing central nerve system |
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