| WANG Yingxuan,WANG Li,QIAO Guangyu.Serum hormone and target organ responses after irradiation of hypothalamus with various doses[J].Chinese Journal of Radiological Medicine and Protection,1999,19(4):248-250 |
| Serum hormone and target organ responses after irradiation of hypothalamus with various doses |
| Received:January 25, 1999 Revised:March 10, 1999 |
| DOI： |
| KeyWords:Radiation response Hypothalamus Serum hormone |
| FundProject:全军“九五”课题基金 |
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| Abstract:: |
| Objective To detect radiation response of neuroendocrine function after single dose irradiation to hypothalamus and to provide a fundamental study for SRS and SRT. Methods Porcine hypothalamus regions were irradiated by 5, 10, 15 and 20 Gy with 10 MV X-rays.The serum levels of testosterone, T3, T4 and cortisol were measured.At the 40th week, hypothalamus, testes, thyroids and adrenals were obtained for histopathological examination. Results Significant gliosis in hypothalamus region irradiated with 15 and 20 Gy was observed by electron microscopy.The serum testosterone levels declined in all irradiated groups but it was recovered to normal afterward in 5 Gy group.Remarkable atrophy in testis insterstitia was noticed in 15 Gy and 20 Gy groups at the 40th week after irradiation.No significant changes in T3 and T4 levels were found, but the degeneration of the thyroids was observed in 15 Gy and 20 Gy groups. Conclusions Hypothalamus is vulnerable to radiation, 5 Gy single dose irradiation is well tolerated and single dose above 10 Gy may cause significant deficiency in the GnRH secretion.TRH cells of hypothalamus may maintain normal function after 5-20 Gy single dose irradiation. |
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