| ZHOU Ying,QU Wanying,YAO Zhiming.Experimental study of hypoxia imaging agent 99m Tc-HL91 in mice bearing glioblastoma G422[J].Chinese Journal of Radiological Medicine and Protection,1999,19(3):198-200 |
| Experimental study of hypoxia imaging agent 99m Tc-HL91 in mice bearing glioblastoma G422 |
| Received:March 01, 1999 Revised:April 26, 1999 |
| DOI： |
| KeyWords:Technetium-HL91 Mice Glioblastoma |
| FundProject:国家攀登计划B项目资助 |
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| Abstract:: |
| Objective To evaluate the ability of detecting cerebral tumor by 99m Tc-HL91 in mice bearing glioblastoma G422. Methods Six model mice underwent static whole body planar imagings at once and at 1,2,3,4,6,7,8h postinjection of 99m Tc-HL91.Three mice each were killed at 4h and 8h,respectively.The tumor,blood and organs were removed,weighted and the radioactivity was measured.ROIs were drawn around tumor,head,contralateral axilla and chest in whole body planar images,and the radioactivity ratios of tumor to head (T/H),contralateral axilla (T/A) and chest (T/C) were calculated. Results Increased tumor activity was indentified in static whole body planar images since 1h postinjection.At 2h postinjection,T/H,T/A and T/C were 2.93±0.51,4.86±0.79 and 2.00±0.35 respectively,which were significantly higher than those at once and at 1h postinjection ( P <0.05, P <0.01).The radioactivity ratios in per unit weight of tumor to blood,muscles,brain,heart and lungs at 4h postinjection were much higher than those of tumor to liver,spleen,stomach,intestines and kidneys. Conclusion Retention ratio of 99m Tc-HL91 in tumor tissue of mice bearing glioblastoma G422 is increased and clearance rate is decreased. 99m Tc-HL91 imaging is suitable for gliblastoma at 2h postinjection.It is appropriate to image tumors in head,neck,thorax,bone and soft tissues,but not in abdominal area. |
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