| SUN Meizhen,YANG Zhaohua,NI Zhenli.Structure activity relationship study of chelating agents of double molecular substituted phenols amino carboxylic acid for decorporated radiothorium[J].Chinese Journal of Radiological Medicine and Protection,1999,19(3):183-185 |
| Structure activity relationship study of chelating agents of double molecular substituted phenols amino carboxylic acid for decorporated radiothorium |
| Received:April 19, 1998 Revised:July 21, 1998 |
| DOI： |
| KeyWords:Chelating agent Thorium-234 Decorporated bioactivity |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | SUN Meizhen | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China | | YANG Zhaohua | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China | | NI Zhenli | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China | | 陈桂宝 | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China | | 刘实晶 | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China | | 陈红红 | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China | | 罗梅初 | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China |
|
| Hits: 2757 |
| Download times: 1507 |
| Abstract:: |
| Objective To study the effects of synthesized chelating agents of double molecular substituted phenols amino carboxylic acid on decorporated radiothorium in rats and to explore the relationship between their chemical structure and bioactivity. Methods Chelating agents could increase the excretion of 234 Th in urine and feces and decrease its retention in liver and skeleton of rats as compared with the control group. Results The chelating agents showed different bioactivity for decorporated thorium except 4 agents.Three of them could increase excretion of 234 Th in urine and feces by 60-70% and decrease markedly retention of 234 Th in liver and skeleton. Conclusion Chelating agents of the catechol series have been proved to be superior to others.They are the best ones while the resorcinol is the worst and hydroquinone is ranked between them. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
