| SU Xu,LIU Jianxiang,ZHANG Yingchun.Adaptive response of thymocytes and its subsets induced by low dose whole body irradiation with X-rays in mice[J].Chinese Journal of Radiological Medicine and Protection,1999,19(3):174-176 |
| Adaptive response of thymocytes and its subsets induced by low dose whole body irradiation with X-rays in mice |
| Received:September 14, 1998 Revised:February 01, 1999 |
| DOI： |
| KeyWords:Low dose irradiation Adaptive response Thymocytes subsets |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | SU Xu | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China. | | LIU Jianxiang | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China. | | ZHANG Yingchun | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China. | | 鞠桂芝 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China. | | 刘树铮 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China. |
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| Abstract:: |
| Objective To study the changes in expression of TCR,CD3 CD4 and CD8 molecules on thymocytes following irradiation with low dose X-rays before a challenge dose in mice. Methods Kunming mice were irradiated with 0.075 Gy (conditioning dose) 6 hours before 1.5 Gy irradiation (challenge dose).The expression of TCR,CD3,CD4 and CD8 were analyzed by flow cytometry 18 hours after 1.5 Gy irradiation. Results It was found that the TCR+,CD3+,CD4-CD8+,CD4+CD8- and CD4-CD8 + positive cells were decreased significantly after only 1.5 Gy irradiation.However,the extent of depression of TCR +,CD3+,CD4+CD8+,CD4+CD8- and CD4-CD8+ was diminished when a dose of 0.075 Gy was given 6 hours before 1.5 Gy.The results suggest that pre irradiation with 0.075 X-rays can significantly reduce the damage of thymocytes and the matured subsets induced by 1.5 Gy iradiation. Conclusion The results indicate that adaptive response of TCR+,CD3+,CD4 +CD8 +,CD4+CD8- and CD4-CD8+ subsets of thymocytes can be induced by whole body irradiation with 0.075 Gy X-rays. |
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