| JIANG Tao,HAYATA I,WANG Cunyan,et al.Dose effect relationship in production of dicentrics and rings in blood lymphocytes of individuals living in high background radiation area[J].Chinese Journal of Radiological Medicine and Protection,1999,19(2):104-107 |
| Dose effect relationship in production of dicentrics and rings in blood lymphocytes of individuals living in high background radiation area |
| Received:July 10, 1998 Revised:October 10, 1998 |
| DOI： |
| KeyWords:High background radiation Chromosome aberrations Dose effect relationship |
| FundProject: |
| Author Name | Affiliation | | JIANG Tao | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | HAYATA I | 日本科技厅放射线医学综合研究所 | | WANG Cunyan | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 中井斌 | 日本体质研究会 | | 姚素艳 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 袁镛龄 | 湖南省劳动卫生研究所 | | 戴连连 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 刘青杰 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 陈德清 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 魏履新 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 菅原努 | 日本体质研究会 |
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| Abstract:: |
| Objective To explore the dose effect relationship in the production of chromosome aberrations by high background radiation by using statistically appropriate individual measurements. Methods Chromosome analysis was performed in separated blood lymphocytes of 39 family memders of different ages from either high background radiation area(HBRA) or control area (CA).Individual cumulative doses ranged from 23.9-261.3 and 5.2-29.8 mGy for HBRA and CA,respectively.A total of about 100,000 cells were scored and dicentric and ring chromosome (dic+Rc)aberrations recorded.Results In the case of HBRA,individual chromosome aberration frequencies increased with age within each family.The increasing trend was in general not significantly different among families.The increase in individual aberration was closely correlated with age and cumulative dose.Age-and dose effect relationship fit well the linear equation:Y=0.0448X+0.4913(R2=0.7814)for age and Y=0.0156X+0.5715(R2=0.7061)for cumulative dose,respectively.In the case of CA,there was no significant difference in aberration yields among individuals of different ages,and the group mean aberration frequency was 1.24±0.69×10-3 . Conclusiones Dic and Rc can continuously accumulate over a liftime chronic low dose exposures,and can serve as a reliable biological indicattor.However,the ultimate sensitivity is about 50 mGy. |
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