| SUN Quanfu,ZOU Jianming,AKIBA S,et al.Data pooling and statistical analyses of cohort studies (1979-1995) in Yangjiang, China[J].Chinese Journal of Radiological Medicine and Protection,1999,19(2):95-98 |
| Data pooling and statistical analyses of cohort studies (1979-1995) in Yangjiang, China |
| Received:October 08, 1998 Revised:November 15, 1998 |
| DOI： |
| KeyWords:Cohort study Database Record linkage Risk analysis |
| FundProject: |
| Author Name | Affiliation | | SUN Quanfu | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | ZOU Jianming | Guangdong Institute of Prevention and Treatment of Occupational Diseases, Guangzhou 510310, China | | AKIBA S | Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan | | 刘玉升 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 李嘉 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 陶祖范 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088, China | | 查永如 | Guangdong Institute of Prevention and Treatment of Occupational Diseases, Guangzhou 510310, China | | 袁镛龄 | 湖南省劳动卫生研究所 | | 加藤宽夫 | 日本放射线影响研究所 | | 魏履新 | Laboratory of Industrial Hygiene, Ministry of health, Beijing 100088, China |
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| Abstract:: |
| Objective Cohort studies on cancer mortality among inhabitants in the high background radiation area (HBRA) of Yangjiang,China,was started in 1972.The purpose of the investigation was to explore cancer risks associated with chronic exposure to low dose ionizing radiation.In this paper,we describe data pooling and methods of cancer risk estimation used in Yangjiang HBRA study. Methods HBRA epidemionogical surveys were carried out in consecutive periods,i.e.,retrospective survey (1970-1978),dynamic population follow up (1979-1986),and fixed cohort study (1987-1995).The surveys included tracing and folow up of cohort members,ascertainment of causes of death,and measurements of indoor/outdoor gamma exposure and individual cumulative doses.Record linkage was used to combine the follow up data of the dynamic population (1979-1986) and the fixed cohort (1987-1995).Risk analysis was based on detailed tabulation of person years stratified by sex,age at risk,follow up interval,and dose group.The basic data for each cell in these tables included the numbers of cancer deaths,other deaths interested,and person years.These data were supplemented by cell-specific person year weighted means of cumulative doses and age at risk.The person year tabulations were prepared using DATAB in Epicure.Standard Poisson regression method was used to estimate excess relative risk per sievert,and relative risks for each dose groups in HBRA compared with control group.Significance test (two-sided P value) and 95% confidence intervals were calculated by χ 2 approximation to likelihood ratio method.Risks were estimated using AMFIT in Epicure. Results Due to differences in date of birth of some subjects and other reasons,about ten percent of subjects failed to link.Conclusione Cancer risk analysis was based on the pooled data for the period 1979 1995,which included 125079 subjects,accumulated 1698350 person-years,and observed 1003 cancer cases among 10415 deaths.Cancer risks are discussed in another paper. |
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