| ZOU Jianming,SUN Quanfu,YUAN Yongling,et al.A case control study of nasopharyngeal carcinoma among inhabitants in high background radiation areas of Yangjiang, China[J].Chinese Journal of Radiological Medicine and Protection,1999,19(2):90-94 |
| A case control study of nasopharyngeal carcinoma among inhabitants in high background radiation areas of Yangjiang, China |
| Received:October 08, 1998 Revised:November 15, 1998 |
| DOI： |
| KeyWords:High background radiation Nasopharyngeal carcinoma Case control study odd ratio |
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| Abstract:: |
| Objective The purpose of the study was to confirm and explore main risk factors of nasopharyngeal carcinaoma (NPC) in cohort members of the investigated areas,and evaluate effects of confounding factors on cancer risk associated with exposure to high background radiation. Methods The deceased cases of NPC during the period of 1987-1995 were selected as study subjects for each of whom two controls were randomly selected from potential control subjects who died from causes other than malignant tumors and external causes,and matched for sex and years of birth and death (within 5 years).Using structure questionnaire,the relevant information including socioeconomic status,dietary habits,smoking and alcohol consumption,history of illness,agricultural use of pesticide,medical X-ray exposure and familial history of NPC were collected.The odds ratio (OR) was used as a measure of association between NPC and the risk factors. Results 102 cases and 202 controls were successfully investigated.Single factor conditional logistic regression analysis showed that the occurrence of NPC was closely positively associated with intake of salted fish,pickles,fermented soybeans,cured meats,history of chronic rhinits and familial history of NPC.Further multiple conditional logistic regression analysis turned out that intake of salted fish,history of chronic rhinits and familial history of NPC were the the independent risk factors of NPC.After controlling for history of chronic rhinits and familial history of NPC,the results based on multiple conditional logistic regression analysis from high background radiation,intake of salted fish and fermented soybeans,tobacco smoking and alcohol consumption showed that only intake of salted fish was a significant risk factor (OR=2.8,95%CI 1.52-5.18),tobacco smoking (OR=1.2,95%CI 0.65-2.22),alcohol consumption (OR=0 83,95%CI 0.38-1.78) and exposure to high background radiation (OR=0.86,95%CI 0.44-1.68) did not increase risk of NPC. Conclusiones alted fish consumption was closely associated with an increased risk of NPC,and exposure to high background radiation in the HBRA was not a significant risk factor of NPC. |
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