| LUO Qingliang,Neelis KJ,Wagemaker G.Therapeutic effect of TPO and G CSF on acute radiation sickness of monkeys[J].Chinese Journal of Radiological Medicine and Protection,1999,19(1):34-38 |
| Therapeutic effect of TPO and G CSF on acute radiation sickness of monkeys |
| Received:August 12, 1998 Revised:November 12, 1998 |
| DOI： |
| KeyWords:Thrombopoietin Granulocyte colony stimulating factor Acute radiation sickness Hematopoietic growth factor |
| FundProject: |
| Author Name | Affiliation | | LUO Qingliang | Beijing Institute of Radiation Medicine, Beijing 100850, China | | Neelis KJ | Institute of Hematology, Erasmus University, Rotterdam, 3000DR Rotterdam, The Netherlands | | Wagemaker G | Institute of Hematology, Erasmus University, Rotterdam, 3000DR Rotterdam, The Netherlands |
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| Abstract:: |
| Objective This report describes the therapeutic effects of recombinant human thrombopoietin(rhTPO) and recombinant human granulocyte colony stimulating factor(rhG-CSF) on acute radiation sickness in monkeys.Methods rhTPO(10μg·kg -1 ·d -1 ,sc,on days 1-21 after TBI)or/and rhG-CSF(5μg·kg -1 ·d -1 ,sc,on days 1-21 after TBI) were administered to rhesus monkeys with 5.0Gy X-irradiation.Results rhTPO promoted platelet and reticulocyte recovery,resulting in less profound nadirs and a rapid recovery to normal levels.Platelet transfusions were not required in contrast to controls,while hemoglobin levels stabilized rapidly.TPO treatment did not influence neutrophil counts, rhG-CSF stimulated neutrophil regeneration and had no effect on platelet levels.Simultaneous administration of rhTPO and rhG GSF were as effective as rhTPO alone in preventing thrombopenia,although the platelet level did not rise to the supranormal level seen with TPO alone. The neutropils were greatly augmented in number,compared to G-CSF treatment alone,resulting in a less profound nadir and much earlier recovery,which was similarly observed for monocytes,CD11 b+,CD+16 and CD+56 cell reconstitution. Conclusion These data show that rhTPO and rhG-GSF are potent stimulators of hematopoiesis in monkeys with radiation sickness. |
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