| AI Guoping,SU Yongping,LIU Xiaohong,et al.Relationship between change of small intestinal mucosal immunity and enterogenous infection in mice with combined radiation burn injury[J].Chinese Journal of Radiological Medicine and Protection,1999,19(1):15-17 |
| Relationship between change of small intestinal mucosal immunity and enterogenous infection in mice with combined radiation burn injury |
| Received:September 26, 1998 Revised:November 11, 1998 |
| DOI： |
| KeyWords:Combined radiation burn injury Mucosal immunity Enterogenous infection |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | AI Guoping | Department of Radiation Medicine, Third Military Medical University, Chongqing 400038, China | | SU Yongping | Department of Radiation Medicine, Third Military Medical University, Chongqing 400038, China | | LIU Xiaohong | Department of Radiation Medicine, Third Military Medical University, Chongqing 400038, China | | 王东海 | 解放军第二六四医院烧伤科 | | 王军平 | Department of Radiation Medicine, Third Military Medical University, Chongqing 400038, China | | 程天民 | Department of Radiation Medicine, Third Military Medical University, Chongqing 400038, China | | 冉新泽 | Department of Radiation Medicine, Third Military Medical University, Chongqing 400038, China |
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| Abstract:: |
| Objective To explore the change of intestinal mucosal immunity and its relation with enterogenous infection after irradiation or burn alone or both combined.Methods Spot hybridization, immunohistochemistry, ELISA and bacterial culture were used. Results (1) After the three modes of injury the quantity of mucosal sIgA and numbers of IgA secreting plasma cells in the intestine were all significantly decreased, enterogenous infection was increased, the IL-4mRNA expression of mesenteric lymphocytes was reduced, and the damage in the combined radiation burn group was more severe. (2) After treatment with IL-4, the number of plasma cells and the quantity of IgA secretion were obviously increased and the incidence of enterogenous infection was reduced. Conclusion Enterogenous infection is highly related with depression of sIgA mainly owing to reduction of quantity and function of IgA-secreting plasma cells. It is beneficial to enchance the recovery of mucosal immunity and diminish incidences of entergenous infection. |
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