| Liu Qingjie,Chen Deqing.Hormesis of specific IgG antibody to rabies virus in serum of mice irradiated with low dose γ-rays.[J].Chinese Journal of Radiological Medicine and Protection,1998,18(6):403-405 |
| Hormesis of specific IgG antibody to rabies virus in serum of mice irradiated with low dose γ-rays. |
| Received:May 07, 1998 Revised:December 03, 1998 |
| DOI： |
| KeyWords:Humoral immune hormesis Low dose γ-rays Mice Rabies virus Specific IgG |
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| Abstract:: |
| Objective To explore the effect of low dose ionizing radiation on specific antibody in mouse serum.Methods Kunming strain male mice, weighing 18-22 g, aged 6-8 weeks, were immunized intraperitoneally with rabies vaccine after exposure to cobalt 60 γ-rays.The specific IgG antibody against rabies virus in mouse serum was measured.Results (1)The serum levels of specific IgG in mice irradiated with 5-30 cGy γ-rays were significantly elevated in comparison with those in control mice (P<0.01), the optimum stimulating dose being 10 cGy.(2)Exposure to 10 cGy caused significant enhancement and earlier emergence of the peak level of specific IgG in serum.(3)The hormesis of specific IgG to rabies virus induced by 10 cGy γ-rays could last one week at least.Conclusion Low dose ionizing radiation can enhance the level of specific antibody in mouse serum, and this effect can last for one week at least. |
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