Tong Haibao,Jin Yizun,Jiang Chengchuan.Effect of buthionine sulfoximine on glutathione content and radiation sensitivity of glioma cells.[J].Chinese Journal of Radiological Medicine and Protection,1998,18(6):399-402
Effect of buthionine sulfoximine on glutathione content and radiation sensitivity of glioma cells.
Received:July 18, 1997  Revised:October 29, 1997
DOI：
KeyWords:Glioma  Buthionine salfoximine  Glutathione  Radiation sensitivity
FundProject:卫生部基金
Author NameAffiliation
Tong Haibao Institute of Neurology, Shanghai Medical University, Shanghai 200040, ChinaInstitut of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China 
Jin Yizun 上海放射医学研究所 
Jiang Chengchuan 200040 上海, 上海医科大学华山医院神经外科 
严敏芬 上海放射医学研究所 
唐镇生 200040 上海, 上海医科大学华山医院神经外科 
徐立明 上海放射医学研究所 
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Abstract::
      Objective To observe the effect of buthionine sulfoximine (BSO) on glutathione (GSH) content and radiosensitvity of glioma cells. Methods Using Tietze method to detect BSO on cultured glioma cell line and glioma bearing nude mice and MTT method to observe the effect of BSO on radiosensitivity of glioma cells.Results BSO depleted the GSH content of glioma cells effectively and increased the radiation sensitivity. Conclusion Both under hypoxic and aerobic conditions BSO can deplete intracellular GSH and increase the radiation sensitivity of glioma cell.
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