.Radionuclide 235U induced apoptotic cell death in Molt-4 and Ana-1 cell lines.Fu Qiang,Zhang Lansheng, Zhu Shoupeng. Suzhou Medical College,Suzhou 215007,China.[J].Chinese Journal of Radiological Medicine and Protection,1998,18(6):393-395
Radionuclide 235U induced apoptotic cell death in Molt-4 and Ana-1 cell lines.Fu Qiang,Zhang Lansheng, Zhu Shoupeng. Suzhou Medical College,Suzhou 215007,China.
Received:December 22, 1997  Revised:April 25, 1998
DOI：
KeyWords:Radionuclide 235U  Apoptosis
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Author NameAffiliation
付强 200433 上海, 复旦大学遗传所 
张澜生 苏州医学院 
朱寿彭 苏州医学院 
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Abstract::
      Objective The mode of cell death in Molt-4 and Ana-1 cell lines were studied after treatment with radionuclide 235U. Methods The morphological changes, agarose gel electrophoresis, MTT and JAM assays were used for qualitative and quantitative analysis. Result Dying cells induced by 235U displayed the morphological changes of apoptosis.Apoptotic cells and DNA fragmentation induced by 235U in both Molt-4 and Ana-1 cell lines were dependent on the treatment time and accumulated radiation dose.Conclusion Internal exposure with radionuclide 235U induces apoptosis in Molt-4 and Ana-1 cell lines.
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