Zou Zhongmin,Sun Huiqin,Luo Chenji.6Gyγ-irradiation induces apoptosis of bone marrow hematopoietic cells. Zou Zhongmin,Sun Huiqin,Luo Chengji. Department of Radiatio[J].Chinese Journal of Radiological Medicine and Protection,1998,18(6):390-392
6Gyγ-irradiation induces apoptosis of bone marrow hematopoietic cells. Zou Zhongmin,Sun Huiqin,Luo Chengji. Department of Radiatio
Received:December 25, 1997  Revised:March 18, 1998
DOI：
KeyWords:Hematopoietic cells  Apoptosis  Irradiation
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Author NameAffiliation
Zou Zhongmin Department of Radiation Medicine, Third Militury Medical University, Chongqing 400038, China. 
Sun Huiqin Department of Radiation Medicine, Third Militury Medical University, Chongqing 400038, China. 
Luo Chenji Department of Radiation Medicine, Third Militury Medical University, Chongqing 400038, China. 
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Abstract::
      Objective To study the role of apoptosis in radiation induced dysfunction of hematopoiesis.Methods Apoptosis of bone marrow hematopoietic cells (BMHCs) in 6Gy γ irradiated mice was detected by in situ end labelling (ISEL), electron microscopy and flow cytometry.Results Except necrosis, the morphological characteristics of BMHCs after irradiation were consistent with those of apoptosis.The study on time effect relationship showed that the percentage of apoptotic cells in BMHCs reached its peak (about 30%)8h after irradiation and then declined. Conclusion Apoptosis is one of important ways of death of irradiated hematopoietic cells.
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