| Gao Weimin,Zhou Xiangyan.Effect of prenatal exposure to low dose beta radiation from tritiated water on postnatal growth and neuro behavior of rats.[J].Chinese Journal of Radiological Medicine and Protection,1998,18(6):381-385 |
| Effect of prenatal exposure to low dose beta radiation from tritiated water on postnatal growth and neuro behavior of rats. |
| Received:January 08, 1998 Revised:May 27, 1998 |
| DOI： |
| KeyWords:Tritiated water Growth Neurobehaviour Memory Conditional reflex Rats |
| FundProject:卫生部科学研究基金 |
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| Abstract:: |
| Objective Effects of prenatal exposure to HTO(tritiated water) on postnatal growth and neurobehavior of rats were studied by determination of multiple parameters.Methods Pregnant adult Wistar rats were randomly assigned to 4 groups, of which 3 groups were irradiated with beta-rays from tritiated water (HTO) by one single intraperitoneal injection on the 13th day of gestation. Offspring of these rats received cumulative doses of 0.000, 0.044, 0.088 and 0.264 Gy in utero, respectively, and were observed for the appearance of three physiologic markers (eye opening, pinna detachment, incisor eruption), the age of acquisition of two reflexes (surface righting, negative geotaxis) and sensuous function (auditory startle), movement and coordination functions and activity (forelimb hanging, continuous corridor activity), and learning and memory (electric avoidance reflex in Y maze, conditional reflex).Results Results for most parameters in the 0.044 and 0.088 Gy groups were different significantly from those in the controls and for most parameters a dose dependent effect was found. Conclusion Offspring of rats having received prenatal low dose irradiation from HTO showed delayed growth and abnormal neurobehavior. |
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