| Xu Hui,Cheng Tianmin,Su Yongping.Effects of 8Gy whole body irradiation on number and functions of small intestinal intraepithelial lymphocytes(IELs).[J].Chinese Journal of Radiological Medicine and Protection,1998,18(6):373-376 |
| Effects of 8Gy whole body irradiation on number and functions of small intestinal intraepithelial lymphocytes(IELs). |
| Received:February 25, 1998 Revised:April 27, 1998 |
| DOI： |
| KeyWords:Radiation Intraepithelial lymphocytes Cell proliferation Cytotoxine |
| FundProject:全军“九五”指令性攻关课题资助 |
| Author Name | Affiliation | | Xu Hui | Research Institute of Combined Injury, Faculty of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | Cheng Tianmin | Research Institute of Combined Injury, Faculty of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | Su Yongping | Research Institute of Combined Injury, Faculty of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 阎国和 | Research Institute of Combined Injury, Faculty of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 林远 | Research Institute of Combined Injury, Faculty of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 古德全 | Research Institute of Combined Injury, Faculty of Preventive Medicine, Third Military Medical University, Chongqing 400038, China |
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| Abstract:: |
| Objective To explore the characteristics of intestinal mucosal immunity after radiation injury. Methods Number, proliferation activity, cytotoxicity of IEL as well as the TNF-α and TGF-β concentrations in supernatant of cultured IELs were studied using freshly isolated IELs from whole small intestine of Kunming strain mice whole body irradiated with 8Gy 60Co rays.Results The proliferation activity, cytotoxicity as well as the number of IELs in small intestinal mucosa were significantly decreased from 8h and reached the lowest level at 72h post irradiation. The TNF-α and TGF-β concentrations in supernatant of cultured IELs isolated from irradiated mice elevated at 8h and reached the peak values at 72h.Conclusion The decrease in number and important functions of IELs might be one of the reasons which damage the intestinal mucosal immunity barrier after whole body irradiation. |
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