| Xie Feng,Su Xu,Liu Shuzheng.Time course of intracellular free Ca2+ concentration changes in thymocytes after whole body irradiation with X-rays[J].Chinese Journal of Radiological Medicine and Protection,1998,18(5):351-353 |
| Time course of intracellular free Ca2+ concentration changes in thymocytes after whole body irradiation with X-rays |
| Received:January 20, 1997 Revised:June 09, 1997 |
| DOI： |
| KeyWords:Low dose radiation Intracellular free Ca2+ concentration Signal transduction Fluorescence probe |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Xie Feng | Radiobiology Research Unit, Ministry of Health, Norman Bethune University of Medical Sciences, Changchun 130021, China | | Su Xu | Radiobiology Research Unit, Ministry of Health, Norman Bethune University of Medical Sciences, Changchun 130021, China | | Liu Shuzheng | Radiobiology Research Unit, Ministry of Health, Norman Bethune University of Medical Sciences, Changchun 130021, China |
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| Abstract:: |
| Objective The purpose of the present study was to look at the possible influence of whole body irradiation (WBI) with X-rays on the intracellular free Ca2+ concentration [Ca2+]i in thymocytes and to elucidate the possible molecular mechanism of immunoenhancement following low dose radiation (LDR).Method [Ca2+]i was assayed by fluoresence spectrophotometry after loading the thymocytes with a fluorescence probe (Fura-2AM).Result It was found that [Ca2+]i increased after WBI with 75mGy X-rays, reaching its peak at 24h and returning to control level within 72h.Conclusion The results indicate that LDR can promote signal transduction of T lymphocytes. |
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