| Sun Rui,Tian Zhigang,Wang Junfu,et al.Recombinant human interleukin 6 protects mice from lethal irradiation and has effects on platelets[J].Chinese Journal of Radiological Medicine and Protection,1998,18(4):273-275 |
| Recombinant human interleukin 6 protects mice from lethal irradiation and has effects on platelets |
| Received:February 24, 1998 Revised:April 21, 1998 |
| DOI： |
| KeyWords:rhIL-6 Ionizing radiation Platelets Hematopoiesis Survival |
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| Abstract:: |
| Objective To study the effects of rhIL-6 on platelets and its possible utilization in irradiation induced myelosuppression.Methods The rhIL-6 (5μg/day ×7 days) was injected into lethally irradiated C57BL/6 mice before or after irradiation. Results The survival was significantly prolonged by rhIL-6 administration either before or after irradiation when compared with HBSS group (P<0.01).The mean survival period prolonged from 9.3 days to 12.7 days(rhIL-6 administration after irradiation) or to 11.5 days (rhIL-6 administration before irradiation).rhIL-6 enhanced the contents of RBC, HGB, HCT and PLT. Conclusion The research indicates that rhIL-6 may improve platelets and be a possibly potential candidate for the treatment of irradiation induced myelosupression in clinic. |
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