| Xiang Yingsong,Yang Rujun,Min Rui,et al.Therapy for acute radiation disease with bone marrow transplantation enhanced by fetal liver stromal cells in mice[J].Chinese Journal of Radiological Medicine and Protection,1998,18(4):249-252 |
| Therapy for acute radiation disease with bone marrow transplantation enhanced by fetal liver stromal cells in mice |
| Received:September 10, 1997 Revised:October 27, 1997 |
| DOI： |
| KeyWords:Bone marrow transplantaition Niche Fetal liver stromal cells Graft versus host disease Acute radiation disease |
| FundProject:国家自然科学基金 |
| Author Name | Affiliation | | Xiang Yingsong | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | Yang Rujun | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | Min Rui | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 蔡建明 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 杨平 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China |
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| Abstract:: |
| Objective To enhance the grafting efficiency of bone marrow transplantation (BMT). Method The survival rate of mice, hematopoietic reconstitution, and reduction of acute graft versus host disease (GVHD) were studied in an acute radiation disease model of Kunming mice by a new method of BMT enhanced by addition of fetal liver stromal cells (BMT-FLSt).Results WBC and nucleated cell counts and indexes of restored to normal CFU-E, CFU-GM, CFU-S, especially CFU-F, in BMT-FLSt group were significantly higher than those in the group with BMT alone 11 days after irradiation.And all those indxes in BMT-FLSt group returned to normal 17 days after irradiation.The survival rate of mice in BMT-FLSt group (60%) was also significantly higher than that in the group with BMT alone (30%), and the degree of GVHD in BMT-FLSt group was slighter than that in the group with BMT alone. Conclusion These data suggested that hematopoietic microenvironment could be improved, and "niches" could be both improved and increased by fetal liver stromal cell transplantation; so, fetal liver stromal cells could prompt hematopoietic reconstitution and enhance engrafting efficiency. |
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