| Gao Shenyong,Sun Wenji,Zhang Aizhen,et al.Long term follow up observation of patients with chronic radiation sickness due to external irradiation treated with thymopeptide[J].Chinese Journal of Radiological Medicine and Protection,1998,18(4):244-246 |
| Long term follow up observation of patients with chronic radiation sickness due to external irradiation treated with thymopeptide |
| Received:November 13, 1997 Revised:February 05, 1998 |
| DOI： |
| KeyWords:Chronic radiation sickness External irradiation Thymopeptide Follow up observation Judgement criteria |
| FundProject: |
| Author Name | Affiliation | | Gao Shenyong | Dept.of Radiation Medicine, The First Affiliated Hospital of Zhejiang Medical University, Hangzhou 310003, China | | Sun Wenji | Dept.of Radiation Medicine, The First Affiliated Hospital of Zhejiang Medical University, Hangzhou 310003, China | | Zhang Aizhen | Dept.of Radiation Medicine, The First Affiliated Hospital of Zhejiang Medical University, Hangzhou 310003, China | | 叶安方 | Dept.of Radiation Medicine, The First Affiliated Hospital of Zhejiang Medical University, Hangzhou 310003, China |
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| Abstract:: |
| Objective To provide the clinical data and prognosis judgement, we observed the results and progression of 11 cases of chronic radiation sickness due to external irradiation treated with thymopeptide.Methods The clinical symptoms, hematopoiesis, T lymphocyte percentage and chromosome aberration rate were used as the judgement indexes for recovery from the chronic radiation sickness.Results Thymopeptide treatment greatly improved the neurasthenic syndrome and increased the T lymphcyte percentage(P<0.05), which could enhance the patients' cellular immunity and cure ulcerative stomatitis.The follow up observation showed that cellular immunity returned to normal level after 2 years(P>0.05), and improvement of neurasthenic syndrome occurred 3.5 years after they left radiation work or diminished the exposure level.5 to 8 years after, bone marrow hematopoiesis also restored to the normal level.However, the chromosome aberration rate restored to the normal level 10 years after.Conclusion According to our judgement criteria, the chronic radiation sickness due to external radiation exposure can recover and thymopeptide is a helpful and simple means to treat it. |
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